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The effect of modifications in resistance training parameters on blood pressure values during and after the training session.
Juřík, Roman ; Šťastný, Petr (advisor) ; Petr, Miroslav (referee) ; Uhlíř, Petr (referee)
Author: Mgr. Roman Juřík Title: The effect of modifications in resistance training parameters on blood pressure values during and after the training session. Objective: The aim of this study was to evaluate the acute effect of various forms of agonist- antagonist paired set and agonist resistance training on selected cardiovascular parameters in individuals with normal blood pressure and stage I hypertension. Methods: This research was conducted as a single-blind, controlled study. Based on a systematic literature search, specialized resistance and aerobic training sessions were designed. The program lasted four weeks and included a familiarization phase lasting one week. Prior to the cross-sectional study, anthropometric measurements, biochemical sample collection, muscle strength and fitness testing, and subjective assessment of training intensity using the Borg Scale were conducted. The study consisted of four different resistance training sessions and one aerobic session. Resistance training were categorized into two basic methods: agonist- antagonist paired set and traditional (agonist) training, as well as based on targeted muscle groups (upper and lower body). Training variables were defined as follows: resistance load at 75 % of 1RM, rest interval between exercises and sets of 90 seconds, 3...
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Molecular mechanisms linking adipose tissue dysfunction and atherosclerotic complications
Kratochvílová, Helena ; Haluzík, Martin (advisor) ; Bužga, Marek (referee) ; Cibičková, Ľubica (referee)
Obesity and its associated comorbidities increase the risk of mortality. The development of subclinical inflammation associated with obesity also plays a significant role in this. In our work, we focused on changes in the endocrine and mitochondrial function of adipose tissue and their relationship to cardiovascular complications. The first part of the thesis focuses on determining the expression of mitochondrial and endoplasmic reticulum genes in epicardial and subcutaneous adipose tissue, intercostal muscle or right myocardial atrium in patients with atherosclerotic coronary artery disease. Patients with coronary artery disease had reduced expression of several mitochondrial chain genes in epicardial adipose tissue compared to subcutaneous adipose tissue and other tissues, while no change in endoplasmic reticulum gene expression in the above-mentioned tissues has been demonstrated. Based on decreased mitochondrial gene expression in patients with coronary artery disease, we conclude that mitochondrial dysfunction of epicardial adipose tissue may contribute to the development of coronary atherosclerosis. The second part of the thesis is focused on neudesin, new potentional regulator of energy metabolism, in obese patients with type 2 diabetes mellitus (T2DM), who underwent various weight reduction...
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Characterization of epicardial, pericardial, and perivascular adipose tissue in humans and mice
Rybová, Aneta ; Bardová, Kristina (advisor) ; Kuneš, Jaroslav (referee)
Heart-associated adipose tissue plays an important role in the physiology of the cardiovascular system. Not only does it serve as a protection against mechanical and thermal stress, but it also provides energy for the cardiomyocytes. On the other hand, it can also act as a tissue that promotes a proinflammatory state around the heart, which can result in the development of cardiovascular diseases. Information from the study of epicardial, perivascular or paracardial and other adipose tissue surrounding the heart and large vessels may be used in the prevention of pathological conditions of the heart that are associated with the presence of this adipose tissue.
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Gender differences in mortality from cardiovascular diseases in Europe
Trčková, Tereza ; Kulhánová, Ivana (advisor) ; Hulíková Tesárková, Klára (referee)
Genderdifferencesinmortalityfromcardiovascular diseases inEurope Abstract This thesis aims to analyze the difference in cardiovascular disease mortality between men and women in 21 selected European countries in the period 2001-2019. The intensity of gender differences across the selected countries is examined. With a stronger emphasis, the position of the Czech Republic within Europe is evaluated. To examine gender differences in cardiovascular mortality, the thesis uses standardized cause-specific mortality rates and a comparison of actual life expectancy with hypothetical life expectancy when cardiovascular mortality is suppressed for each country. Cluster analysis is used to identify how countries cluster together based on their similarity of health determinants. The results of the analysis showed that differences between men and women are present in all selected countries. The largest differences are found in Eastern and Central European countries.
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Validation of the PCR method for the determination of isotype variants in the ApoE gene
SÝKOROVÁ, Klára
Apolipoprotein E (APOE) was discovered in the early 1970s as a 34 kDa polypeptide of 299 amino acids. It plays an important role in the metabolism of cholesterol and triglycerides. It is an important component of VLDL, HDL and chylomicrons. The APOE gene is located on the long arm of chromosome 19 in region 19q13.32. It consists of three introns and four exons. It occurs in three alleles e2, e3 and e4, which encode three different isoforms. The isoforms differ in two amino acids (arginine and cysteine) at positions 112 and 158. The e3 allele is the most common, the rarer alleles e2 and e4 are associated with various types of diseases, such as cardiovascular disease, Alzheimer's disease or type III hyperlipoproteinaemia. The aim of my bachelor thesis was to write a research on the topic using information obtained from available proffesional publications, to master basic methods of molecular biology (which include DNA isolation, DNA concentration measurement, preparation of PCR reaction and gel electrophoresis) and to perform PCR method validation. The theoretical part contains general information about lipoproteins, associated with them lipoprotein metabolism and apolipoproteins. It also includes knowledge of the APOE gene, its product and the effect of APOE on various diseases. Finally, there is an overview of laboratory methods used for genetic analysis of isotype variants in the APOE gene. The practical part, which I did in the genetic laboratory GENLABS s.r.o in České Budějovice, includes the analysis of the APOE genotype and the validation of the PCR method, which was successful. Therefore, the method can be included in the daily operation of the laboratory.
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Spatial patterns of links between temperature extremes and cardiovascular mortality in the Czech Republic
Urban, Aleš ; Kyselý, Jan (advisor) ; Huth, Radan (referee) ; Dobrovolný, Petr (referee)
Name of the thesis: Spatial patterns of links between temperature extremes and cardiovascular mortality in the Czech Republic Author: Mgr. Aleš Urban Previous studies have examined relationships of high and low air temperatures to mortality due to cardiovascular diseases (CVDs) in the Czech Republic as a whole. Much less has been understood about possible regional differences in the heat and cold effects on mortality. Within four papers published in international peer-reviewed journals, the author of this thesis investigated links between extreme temperatures and CVD mortality in the Czech Republic while considering in particular differences between (i) urban and rural areas, (ii) regions with different socioeconomic status, and (iii) regions with different physical-environmental conditions. Various biometeorological approaches were compared in order to identify meteorological characteristics affecting heat- and cold-related mortality. Excess mortality was determined as differences between observed and expected daily values, the latter being adjusted for long-term changes, annual and weekly cycles, and epidemics of influenza/acute respiratory infections. Air temperature, biometeorological indices (including the Universal Thermal Climate Index, Apparent Temperature, and Physiologically Equivalent...
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Obesity its causes and cosequences
Ondráčková, Anna ; Vybíral, Stanislav (advisor) ; Kuda, Ondřej (referee)
Obesity is one of the most common health problems in the Word. Over 500 million adults and over 40 million children are obese. The aim of this work is to summarize findings of causes and consequences of this health problem. Even though in some cases only genetic mutations are responsible for obesity for example mutation in ob gene or Prader-Willi syndrome most cases are caused by lifestyle of people -excessive food intake and insufficient physical activity. There are many health problems accompanying obesity. The most serious problems are metabolic syndrome, diabetes mellitus, cardiovascular diseases and cancer. The consequences of obesity are, however, not confined only to health. We can also observe the economic consequences. Financial cost of treatment of obesity and related diseases are estimated in billions of dollars. Pharmacological treatment has so far proved to be ineffective. If drugs are effective, the side effects are so severe that their use is not possible. So far, the adipose tissue hormones that regulate food intake provide the best hope.
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Importance of primary and secondary prevention in cardivascular disorder
Koníčková, Veronika ; Bunc, Václav (advisor) ; Skalská, Marie (referee)
1 Abstract: Title: The importance of primary and secondary prevention of cardiovascular disease Goals: Develop a theoretical basis for the selected topic. Describe the basic principles of primary and secondary prevention, and thus prepare the groundwork for creating questionnaires. Questionnaire compiled to complement the information obtained from the literature on insight into the practice. Confirm or refute the hypotheses chosen on the basis of a questionnaire. Discuss the most frequently occurring phenomena and compare them with the latest reported information. Draw conclusions and recommendations. Method: For the theoretical treatment of the retrieval method was used. I compared the information and inclined to the best proven. The theoretical part resulted in the goals and tasks of work. For the practical part was conducted by questionnaire survey, which has additional information on the issue of primary and secondary prevention. In the end I obtained data compared with information obtained from studying literature. Results: Lack of information on primary and secondary prevention is mainly for young people aged 10-15 years. This trend is accompanied by the deteriorating health situation and the occasional occurrence of the "diseases of civilization", which can produce complications in adulthood....
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Determination of functional capacity level for executing common daily and occupational activities of individuals with cardiovascular disease
Šimková, Klára ; Uhlířová, Jaromíra (advisor) ; Kotková, Karla (referee)
OF BACHELOR THESIS Title of bachelor thesis: Determination of functional capacity level for executing common daily and occupational activities of individuals with cardiovascular disease. This bachelor's thesis summarizes basic information about cardiovascular diseases, its epidemiology, the most frequent causes of their onset, the most frequent types of diseases, onset risk factors and their prevalence. Subsequently, it is devoted to description of procedures, phases and goals of rehabilitation in the target group of individuals. Particular attention is payed to ergo-therapeutic intervention and options to assess functional capacity in common daily activities and activities related to occupation of individuals with cardiovascular disease. The thesis is divided into theoretical and practical part. The theoretical part, consisting of literature research, summarizes basic knowledge about cardiovascular diseases, its rehabilitation and options to assess functional capacity of affected individuals in different stages of the rehabilitation process. The practical part consists of case interpretations of two patients and processes data from questionnaire-based research. The questionnaire is aimed to collect information from workplaces with department of cardiology and rehabilitation. It processes...
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